จากงานวิจัยหลายเล่มทั่วโลกที่เห็นตรงกันว่า Finally, at the onset of menopause there is a radical change: the production of estrogen decreases significantly and the production of progesterone virtually stops. . This causes a major shift in the fine balance between the two hormones that the body has attempted to maintain to that point. This imbalance leads, inevitably, to the unpleasant menopausal symptoms many women experience.